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KMID : 0043320120350071139
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Archives of Pharmacal Research
2012 Volume.35 No. 7 p.1139 ~ p.1142
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Antibacterial compounds from Zanthoxylum rhetsa
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Tantapakul Cholpisut
Phakhodee Wong
Ritthiwigrom Thunwadee
Yossathera Kulsiri
Deachathai Suwanna
Laphookhieo Surat
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Abstract
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A new amide, zanthorhetsamide (1), along with nine known compounds (2?10) was isolated from the roots and stem barks of Zanthoxylum rhetsa. The structure was characterized by spectroscopic methods. In addition, the antibacterial activity of the isolates was evaluated. Dihydrochelerythrine (4) exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 μg/mL, respectively.
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KEYWORD
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Zanthorhetsamide, Zanthoxylum rhetsa, Rutaceae, Antibacterial activity
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